[Effect of protein deficiency and antigenic stimulation on rat liver lysosomes]

The total and non-sedimentable activities of liver beta-galactosidase, beta-glucoronidase, beta-N-acetyl glucosaminidase, aryl sulfatases A and B were studied during antigenic stimulation of rats fed balanced and low-protein (5% of energy value) diets. Antigenic stimulation of rats fed a balanced diet was found to intensify the total activities of all lysosomal enzymes (up to 124-246% of control). Meanwhile protein deficiency did not cause any significant reduction in immune response and completely removed activation of lysosomal hydrolases.