Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cigarette smoking and platelet adhesion.

R M Pittilo, J M Clarke, D Harris

    British Journal of Haematology
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evolutionary principles underlying neuron subtype encoding and diversification in animals.

    bioRxiv : the preprint server for biology·2026
    Same author

    Prediction-based attention computing: a proof of concept study.

    Virtual reality·2026
    Same author

    Exploring the association between suicidal thoughts, self-injury, and GLP-1 receptor agonists in weight loss treatments: Insights from pharmacovigilance measures and unmasking analysis.

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2024
    Same author

    Qualitative studies conducted alongside randomized controlled trials in oncology: A scoping review of use and rigour of reporting.

    International journal of nursing studies·2022
    Same author

    Adult North Star Network (ANSN): Consensus Document for Therapists Working with Adults with Duchenne Muscular Dystrophy (DMD) - Therapy Guidelines.

    Journal of neuromuscular diseases·2022
    Same author

    Putative intranuclear coccidium in Mauremys leprosa (Schweigger) from Morocco.

    Folia parasitologica·2021
    Same journal

    Response-adapted chimeric antigen receptor T cell (CAR-T)-sparing consolidation radiotherapy in high-risk large B-cell lymphoma (LBCL): Results of the prospective RESTART protocol.

    British journal of haematology·2026
    Same journal

    Prospective, multicentre phase II study to evaluate the clinical benefit of reduced-dose lenalidomide and dexamethasone based on frailty stratification in elderly, unfit patients with newly diagnosed multiple myeloma.

    British journal of haematology·2026
    Same journal

    Real-world effectiveness and safety of acalabrutinib in chronic lymphocytic leukaemia: Multicentre experience.

    British journal of haematology·2026
    Same journal

    Novel germline GATA1s-generating variant associates with somatic STAG2 variants in hypoplastic myelodysplastic neoplasm.

    British journal of haematology·2026
    Same journal

    The Endothelial Activation and Stress Index (EASIX) at diagnosis is associated with survival in primary central nervous system lymphoma.

    British journal of haematology·2026
    Same journal

    Hyperlactataemia in lymphoma-associated haemophagocytic lymphohistiocytosis: Linked to monocytic glycolysis and adverse prognosis.

    British journal of haematology·2026
    See all related articles

    Smoking human blood significantly increases platelet adhesion to rabbit endothelium in vitro. This effect was observed consistently after smoking, indicating a pro-thrombotic shift in blood characteristics.

    Area of Science:

    • Cardiovascular Science
    • Hematology
    • Toxicology

    Background:

    • Endothelial function is crucial for vascular health.
    • Platelet adhesion plays a key role in thrombosis.
    • Smoking is a known risk factor for cardiovascular diseases.

    Purpose of the Study:

    • To investigate the in vitro effect of human blood, before and after smoking, on rabbit endothelium.
    • To assess changes in platelet adhesion following cigarette smoke exposure.

    Main Methods:

    • An in vitro system using a Baumgartner chamber was employed.
    • Rabbit endothelium was exposed to human blood from non-smoking volunteers before and after smoking.
    • Scanning electron microscopy was used to examine endothelial surfaces for platelet adhesion.

    Related Experiment Videos

    Main Results:

    • Blood from volunteers after smoking two medium tar cigarettes showed significantly increased platelet adhesion to the endothelium.
    • Blood samples taken before smoking exhibited very few or no adherent platelets.
    • Control experiments confirmed that the observed effect was due to blood composition changes, not vessel degradation over time.

    Conclusions:

    • Smoking alters human blood, leading to a pro-thrombotic state characterized by increased platelet adhesion.
    • These findings suggest a direct in vitro mechanism by which smoking may contribute to cardiovascular events.