Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function and affective illness: a reappraisal.

R T Joffe, P P Roy-Byrne, T W Udhe

    Biological Psychiatry
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cognitive functions and complaints in HIV-1 individuals treated for depression.

    Applied neuropsychology·2005
    Same author

    Reliability and clinical utility of DSM-IV substance-induced psychiatric disorders in acute psychiatric inpatients.

    The American journal on addictions·2002
    Same author

    The effect of selective serotonin reuptake inhibitor treatment of panic disorder on emergency room and laboratory resource utilization.

    The Journal of clinical psychiatry·2001
    Same author

    A randomized effectiveness trial of collaborative care for patients with panic disorder in primary care.

    Archives of general psychiatry·2001
    Same author

    Lifetime panic-depression comorbidity in the National Comorbidity Survey. Association with symptoms, impairment, course and help-seeking.

    The British journal of psychiatry : the journal of mental science·2001
    Same author

    Panic disorder in primary care: biopsychosocial differences between recognized and unrecognized patients.

    General hospital psychiatry·2000
    Same journal

    Functional connectivity of orbitofrontal cortex predicts cocaine relapse: Protective and risk circuits, individual differences, and neuromodulation implications.

    Biological psychiatry·2026
    Same journal

    Takeda G protein-coupled receptor 5 orchestrates anxiolysis by enhancing anterior paraventricular thalamic nucleus glutamatergic neuronal activity to engage distinct downstream circuits.

    Biological psychiatry·2026
    Same journal

    Neuroimaging of Heterogeneity in Neuropsychiatric Disorders: Toward Disease Progression Modeling.

    Biological psychiatry·2026
    Same journal

    Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

    Biological psychiatry·2026
    Same journal

    Remembering Jon-Kar Zubieta, M.D., Ph.D.

    Biological psychiatry·2026
    Same journal

    Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

    Biological psychiatry·2026
    See all related articles

    Contrary to popular belief, this study suggests that lower thyroid hormone levels, not higher, may indicate a better response to certain antidepressant treatments. This challenges the established view on thyroid function and depression treatment efficacy.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Pharmacology

    Background:

    • The conventional understanding posits that enhanced thyroid function aids antidepressant treatment response.
    • Emerging evidence contradicts this, linking antidepressant efficacy to reduced thyroid hormone levels.

    Purpose of the Study:

    • To propose an alternative hypothesis: decreased thyroid indices correlate with antidepressant response.
    • To discuss the clinical and research implications of this novel perspective.

    Main Methods:

    • Review of recent clinical data on antidepressant treatment outcomes.
    • Analysis of thyroid hormone levels in patients undergoing treatment with agents like lithium and carbamazepine.

    Main Results:

    Related Experiment Videos

  • Observed association between response to specific antidepressants (lithium, carbamazepine) and decreased thyroid hormone levels.
  • Contradiction of the traditional view linking increased thyroid function to treatment success.

    • Conclusions:

    • The hypothesis that decreased thyroid indices predict antidepressant response warrants further investigation.
    • Re-evaluation of the role of thyroid function in depression treatment is necessary, with potential implications for clinical practice and future research.