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Updated: Oct 8, 2026

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Published on: May 4, 2016
[Cytochrome P-450 induction in the liver of rats exposed to polychlorinated biphenyls]
Abstract:
Administration of a mixture of polychlorinated diphenyls (sovol) to rats per os induces a dramatic rise in the liver content of cytochrome P-450. To attain the maximal induction effect, it is sufficient to make a single drug injection in a dose of 500 mg/kg. Further raising of the sovol dose as well as its repeated injections do not exert any substantial effect on the index of hemoprotein induction. Alterations in liver cytochrome P-450 content following a single injection of sovol persist for 40 days. In female rats, the induction effect of sovol is less pronounced than in male rats.
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