Effect of perinatal hypercapnia on the adult ventilatory response to carbon dioxide

Burrowing mammals show a reduced ventilatory response to CO2 and CO2 retention. We examined whether this reduced responsiveness could be due to modification of chemoreceptors by persistent hypercapnia during development. Mice and rats were exposed to 6.0% CO2 throughout gestation and/or weaning and then removed to normocapnic air for a minimum of 6 weeks. Mouse gas pocket O2 and CO2 tensions and hematocrits were analyzed and compared with normocapnically raised controls. The ventilatory and blood gas and pH response to CO2 were compared in chronically cannulated test and control rats. Hematocrits and gas pocket CO2 and O2 tensions of mice and rat ventilatory and arterial blood CO2 and O2 tensions and pH responses were not different in test and control groups. There appears to be little or no developmental affect of CO2 suggesting that the reduced CO2 response seen in burrowers is genetically determined.