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Studies on the glomerular filtration rate and extracellular fluid volume in rhesus monkeys infected with Plasmodium
Abstract:
The glomerular filtration rate (GFR) and the extracellular fluid volume (ECV) were determined in 5 rhesus monkeys infected with P. knowlesi in comparison with 6 control monkeys by using 51Cr-EDTA. As the disappearance curve of the radioactivity showed a close fit to a double exponential equation, the data was therefore analysed by an open 2-compartment system. Results in the present study showed that the GFR was significantly reduced in the infected group. Both V1 and V2 were also slightly but not significantly decreased which resulted in the lower ECV in monkeys infected with P. knowlesi. As the GFR was reduced much more than ECV, therefore the mean transit time of 51Cr-EDTA in the infected group was longer than that of the normal group. All other intercompartment clearance and fractional transfer rate constants were also found to be lower in the infected group. These findings indicated that there was a delay in the distribution of 51Cr-EDTA between these 2 compartments in monkeys infected with P. knowlesi malaria.
Insights
Plasmodium knowlesi malaria significantly reduces glomerular filtration rate (GFR) and extracellular fluid volume (ECV) in rhesus monkeys. This parasitic infection delays fluid distribution, impacting kidney function.
Area of Science:
- Nephrology
- Infectious Diseases
- Primatology
Background:
- Plasmodium knowlesi is an emerging cause of human malaria.
- Kidney function can be affected by malaria infections.
Purpose of the Study:
- To investigate the effects of P. knowlesi infection on glomerular filtration rate (GFR) and extracellular fluid volume (ECV).
- To analyze the distribution kinetics of 51Cr-EDTA in infected rhesus monkeys.
Main Methods:
- Determined GFR and ECV in rhesus monkeys infected with P. knowlesi (n=5) and control monkeys (n=6) using 51Cr-EDTA.
- Analyzed radioactivity disappearance curves using an open 2-compartment model.
Main Results:
- GFR was significantly reduced in the P. knowlesi infected group.
- ECV was slightly decreased, though not significantly.
- Mean transit time of 51Cr-EDTA was longer in infected monkeys, indicating delayed distribution.
Conclusions:
- P. knowlesi malaria significantly impairs GFR in rhesus monkeys.
- The infection causes a delay in the distribution of extracellular fluid, affecting kidney function.