Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Haemodialysis in rats.

A Röckel, A Brand, A Stanjek

Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie

|March 20, 1978

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Value of Routine Pelvic Examination in the Follow-Up of Patients Receiving Adjuvant Radiation Therapy for Endometrial Cancer: An Australian Tertiary-Centre Experience.

Journal of medical imaging and radiation oncology·2025

Same author

Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.

Journal of dental research·2024

Same author

Medical graphics to improve patient understanding and anxiety in elderly and cognitively impaired patients scheduled for transcatheter aortic valve implantation (TAVI).

Clinical research in cardiology : official journal of the German Cardiac Society·2023

Same author

Informed Consent before coronary angiography and percutaneous coronary intervention from the patient's perspective: A picture is worth a thousand words.

International journal of cardiology. Heart & vasculature·2022

Same author

Review of indications for immunoglobulin (IG) use: Narrowing the gap between supply and demand.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2020

Same author

A nurse- and peer-led psycho-educational intervention to support women with gynaecological cancers receiving curative radiotherapy: The PeNTAGOn randomised controlled trial - ANZGOG 1102.

Gynecologic oncology·2020

A novel 1.5 ml extracorporeal blood volume plate dialyser was developed for conscious rats. This device demonstrated effective in vitro clearances, proving suitable for pharmacological and toxicological research.

Area of Science:

Nephrology
Pharmacology
Toxicology

Background:

Dialysis is crucial for removing waste products from blood.
Small animal models are essential for preclinical research.
Developing efficient dialysis methods for conscious small animals presents unique challenges.

Purpose of the Study:

To develop and evaluate a novel plate dialyser for conscious rats.
To assess the in vitro and in vivo functionality of the developed dialyser.
To determine the suitability of this method for pharmacological and toxicological studies.

Main Methods:

Development of a compact plate dialyser with a low extracorporeal blood volume (1.5 ml).
In vitro experiments to measure solute clearances (urea, creatinine, potassium).

Related Experiment Videos

In vivo testing in conscious rats to assess functional performance.

Main Results:

Achieved high in vitro clearances: urea (126+/-9 ml/min/m2), creatinine (70.5+/-9 ml/min/m2), and potassium (132.5+/-13 ml/min/m2).
Demonstrated successful function in conscious rats.
The dialyser's performance indicates efficacy in solute removal.

Conclusions:

The developed plate dialyser is a functional and efficient tool for hemodialysis in conscious rats.
This method is suitable for application in pharmacological and toxicological research.
The low blood volume requirement minimizes physiological stress on the animal model.