Organosilicone induced malformation of rat sperms, a histochemical study

The effects of an organosilicon compound SOC, a derivative of 1,3-dioxa-2-sila-cyclopentane, on rat spermiogenesis were studied with the help of histochemical and enzyme histochemical methods. The rats were injected with SOC i.p. daily for 3 weeks (dosage: 25 mg SOC/kg body weight). Two changes were observed: a) formation of a distinct vacuole within the acrosomal cap of spermatids b) the splitting of the tails of mature sperms.