Coenzymes of methanogenesis from hydrogen and carbon dioxide

Methanogenic bacteria gain their energy for growth from the conversion of a number of simple carbon compounds to methane. With a few exceptions all species known to date are able to reduce CO2 at which hydrogen acts as the electron donor. The reduction of CO2 can formally be considered to proceed through the formyl, the formaldehyde and the methyl level of reduction. These C1-units do not occur as free intermediates, but they remain bound to a number of unique coenzymes during the process. In this paper a survey is given of the structures and functions of these compounds; it deals with methanopterin derivatives, carbon dioxide reduction (CDR) factor, factor F430 and coenzyme M derivatives. A model of the process of methanogenesis that integrates previous ones and that allocates a function to the various coenzymes is presented.