A statistical analysis of Neanthes arenaceodentata, sister chromatid exchange data

This paper presents a statistical evaluation of the sister chromatid exchange (SCE) assay using Neanthes arenaceodentata. Specific issues discussed are distribution of baseline SCE frequencies, transformations of SCE data, statistical sensitivity of the assay, repeatability of test results, and sources of variability of SCE data. Probabilities of false positives and false negatives are considered and recommendations are made for appropriate transformation of data, experimental design, and test conditions.