Gonadotropins pituitary secretion in systemic lupus erythematosus

Hormonal abnormalities have been suggested to play a role in the pathogenesis of systemic lupus erythematosus (SLE). In order to define the regulatory mechanism involved, the pituitary reserve for gonadotropins secretion was investigated in eight untreated SLE patients with normal menstrual cycles. Serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined on the fifth day of the menstrual cycle before and after intravenous administration of 25 micrograms synthetic luteinizing hormone-releasing hormone (LH-RH). The pulsatile LH and FSH resting values in SLE were not significantly higher than those found in the controls; after LH-RH stimulation no difference was observed between the SLE group and controls. The LH and FSH response to exogenous LH-RH administration in SLE demonstrate the integrity of the hypothalamic-pituitary-ovary axis that explains normal menses and fertility in this disease.