Synthesis of new 4 and 5 disubstituted isothiazoles

Synthesis of 24 new 4 and 5 substituted isothiazole derivatives, containing hydrazine and amino groups at the position 5, and carboxyl, ester, amide, hydrazide, nitrile or ureido group in the position 4 is described. Compounds 4, 6, 8 and 19 show antiinflammatory activity, compound 14 has antiaggregatory properties.