Scopulariopsis onychomycosis treated with natamycin

7 patients with Scopulariopsis brevicaulis onychomycosis of the toe-nails were treated locally with 1% natamycin in 60% dimethylsulphoxide. After 3-5 months treatment the fungus could no longer be isolated from the nails, and at follow-up 15 months after the completion of the treatment, 2 patients reported permanent improvement of the nails and 3 a complete cure. In 1 patient the treatment was ineffective.