Related Experiment Videos
Cardiac septal hypertrophy in hyperinsulinemic infants
The Journal of Pediatrics
|March 1, 1980
Summary
Infants of diabetic mothers (IDM) with septal hypertrophy showed profound hypoglycemia. Fetal hyperinsulinemia, not hyperglycemia, may directly cause this cardiac hypertrophy in IDM.
Area of Science:
- Neonatalogy
- Pediatric Cardiology
- Endocrinology
Background:
- Infants of diabetic mothers (IDM) are at risk for cardiac abnormalities.
- Septal hypertrophy is a recognized complication in some IDM.
- The exact cause of septal hypertrophy in IDM remains unclear.
Purpose of the Study:
- To investigate the relationship between septal hypertrophy and neonatal clinical findings in infants of diabetic mothers.
- To explore the potential role of fetal hyperinsulinemia in the development of septal hypertrophy.
Main Methods:
- Echocardiography was used to determine septal hypertrophy (>= 6 mm) in infants.
- Clinical data including hypoglycemia, hypocalcemia, polycythemia, and birth asphyxia were collected.
- Infants with and without septal hypertrophy were compared.
Main Results:
- Five of 18 infants of diabetic mothers and one infant with nesidioblastosis exhibited septal hypertrophy.
- No correlation was found between septal hypertrophy and hypocalcemia, polycythemia, or birth asphyxia.
- All infants with septal hypertrophy presented with profound neonatal hypoglycemia, unlike those without.
Conclusions:
- Profound neonatal hypoglycemia in infants with septal hypertrophy is consistent with fetal hyperinsulinemia.
- The study hypothesizes that fetal hyperinsulinemia, rather than fetal hyperglycemia, directly contributes to septal hypertrophy in infants of diabetic mothers.