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Related Experiment Videos

Rheumatoid disease with encephalopathy.

R C Kim

    Annals of Neurology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A rare case of rheumatoid disease affecting the central nervous system (CNS) involved the choroid plexus, leading to neurological symptoms. This finding highlights the choroid plexus

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    Area of Science:

    • Neuropathology
    • Rheumatology
    • Immunology

    Background:

    • Rheumatoid disease can affect the central nervous system (CNS).
    • Central nervous system (CNS) involvement in rheumatoid disease is often pathologically verified.
    • Previous cases of pathologically verified rheumatoid disease of the CNS have not involved the choroid plexus.

    Observation:

    • A 63-year-old woman presented with progressive rheumatoid disease.
    • The patient exhibited a confusional state, cerebrospinal fluid (CSF) pleocytosis, and hypoglycorrhachia.
    • Neuropathological examination revealed rheumatoid lesions in the cranial dura, falx, and choroid plexus.

    Findings:

    • This is the first reported case of pathologically verified rheumatoid disease of the CNS involving the choroid plexus.

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  • Extensive rheumatoid lesions were found in the cranial dura, falx, and choroid plexus.
  • The patient's symptoms were associated with these neuropathological findings.

    • Implications:

    • The choroid plexus may play a significant role in the development of CNS manifestations in systemic immune complex diseases.
    • These findings expand the understanding of neuropathology in rheumatoid disease.
    • Further research into immune complex deposition in the CNS is warranted.