Reactive angioendotheliomatosis

Angioendotheliomatosis is a rare disorder with both cutaneous and systemic clinical presentations. We agree that there is evidence in the existing medical literature for the separation of reactive and malignant (neoplastic) variants of angioendotheliomatosis. These variants share similar histologic and ultrastructural features but seem clinically distinct. The reactive variant has been associated (four of seven cases, including our patient) with existing or preexisting subacute bacterial endocarditis.