Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Zinc and immune function in Down's syndrome.

B Björkstén, O Bäck, K H Gustavson

    Acta Paediatrica Scandinavica
    |March 1, 1980
    PubMed
    Summary

    This study found that zinc supplementation improved immune function in patients with Down's syndrome (DS). Zinc therapy normalized neutrophil function and enhanced lymphocyte responses, suggesting a link between zinc deficiency and infection susceptibility in DS.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cross-over evaluation of electrically induced pain and hyperalgesia.

    Scandinavian journal of pain·2018
    Same author

    Two-thirds of adolescents who received active perinatal care after extremely preterm birth had mild or no disabilities.

    Acta paediatrica (Oslo, Norway : 1992)·2016
    Same author

    Executive Functioning and Learning Skills of Adolescent Children Born at Fewer than 26 Weeks of Gestation.

    PloS one·2016
    Same author

    Does breast-feeding prevent the development of allergy?

    Immunology today·2014
    Same author

    Low gut microbiota diversity in early infancy precedes asthma at school age.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2013
    Same author

    Evaluation of the effects of a metabotropic glutamate receptor 5-antagonist on electrically induced pain and central sensitization in healthy human volunteers.

    European journal of pain (London, England)·2013

    Area of Science:

    • Immunology
    • Nutritional Science
    • Genetics

    Background:

    • Down's syndrome (DS) is associated with immune deficiencies.
    • Patients with DS exhibit low serum zinc and high blood clot zinc levels.
    • Impaired immune responses, including neutrophil chemotaxis and lymphocyte responsiveness, are observed in DS.

    Purpose of the Study:

    • To investigate the effect of zinc supplementation on immune function in patients with Down's syndrome.
    • To determine if correcting zinc deficiency can improve immune parameters in DS.

    Main Methods:

    • 12 patients with Down's syndrome received zinc sulfate (135 mg Zn++ daily) for 2 months.
    • Immune function was assessed by measuring serum zinc levels, neutrophil chemotaxis, in vitro lymphocyte responsiveness to PHA, and delayed skin hypersensitivity to DNCB.

    Related Experiment Videos

    Main Results:

    • Serum zinc levels increased after zinc therapy.
    • Neutrophil chemotactic responsiveness normalized in 11 of 12 patients.
    • Lymphocyte responses to PHA and delayed skin reactivity improved in most patients.

    Conclusions:

    • Zinc deficiency may contribute to increased infection susceptibility in Down's syndrome.
    • Zinc supplementation can improve key immune parameters in patients with DS.
    • Correcting zinc levels is a potential therapeutic strategy for immune dysfunction in DS.