[Bacteriological investigations with a new Semisynthetic oxy-beta-lactam antibiotic LY 127935 (AUTHOR'S TRANSL)]

The antimicrobial activity of a new oxy-beta-lactam antibiotic LY 127935 against 1066 strains of gram-negative and gram-positive bacterial was evaluated in comparison to cephalothin. The antibiotic has a very wide spectrum and is exceptionally active, in particular against gram-negative rods. It is also active against multiresistant problem strains found in intensive care units (Enterobacter cloacae, Serratia marcescens, indole-positive Proteus), and proved to be quite effective against Pseudomonas aeruginosa. Although LY 127935 is effective against Staphylococcus aureus, cephalothin is superior. Its use is not indicated against Streptococcus faecalis.