[Preservation of the liver (accomplishment, difficulties and prospects)]

The low tolerance of the hepatic tissue to conservation in artificial conditions represents one of the major reasons limiting the application of hepatic transplantation in the clinic. An analysis is carried out of the factors which limit the duration of conservation of the potential graft, by alteration of its biological qualities. These include: ischaemic hypoxia, failure of devices presently used for conservation, spontaneous and progressive reduction of the perfusion flow of the hepatic tissue, insufficient coverage of the metabolic necessities of the organ and the incomplete depuration of the storage medium. Possible remedies are also discussed, in view of improving conservation parameters. The authors's studies can be included in this effort, since they are aimed at improving the perfusion flow of the isolated liver under the effect of streptokynase. Other studies are mentioned, concerned with simultaneous perfusion of the liver and the kidney in view of an efficient depuration of the storage environment.