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Related Experiment Videos

Disappearing carotid defects.

P Yarnell, M Earnest, G Kelly

    Stroke
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Large carotid artery thrombi causing neurological episodes can resolve with heparin treatment or spontaneously. Underlying atherosclerosis may contribute to thrombus formation.

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    Area of Science:

    • Neurology
    • Vascular Surgery
    • Cardiology

    Background:

    • Acute hemispheric neurologic episodes can be associated with large intraluminal cervical carotid artery filling defects.
    • These defects are consistent with mural thrombi, potentially linked to underlying atheromatous disease.

    Observation:

    • Serial angiography revealed the disappearance of these mural thrombi in patients.
    • Thrombi resolved in two patients treated with intravenous heparin.
    • One patient experienced spontaneous resolution after surgical intervention.

    Findings:

    • Partially obstructing cervical carotid artery thrombi can undergo lysis.
    • Resolution can be achieved through anticoagulant therapy (heparin).
    • Spontaneous lysis of carotid artery thrombi is also possible.

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    Implications:

    • Intravenous heparin may be a viable treatment for resolving cervical carotid artery thrombi.
    • Understanding thrombus resolution mechanisms is crucial for managing cerebrovascular events.
    • Atherosclerosis is a potential contributing factor to the formation of these thrombi, highlighting the importance of managing vascular disease.