Genetic tylosis with malignancy: a study of a South Indian pedigree

Tylosis at birth was found as an autosomal dominant inheritance in twenty-two members of a family spanning over five generations. Of those affected three of the fourth generation tylotics developed squamous carcinoma of the tylotic skin and one of these died of carcinoma of the oesophagus. It is possible that there is a genetic association between the state of the oesophagus and the tylosis of the palms and soles which predisposes both sites towards the development of squamous carcinoma.