[Effects of propham and chloropropham on mitosis in cultured human lymphocytes. Ultrastructural study]

Propham and Chloropropham disturb the several mitotic figure components of proliferating human lymphocytes. The tubular structures, affected in preference by the C.I.P.C., become abnormal, disorganized or disappear. The chromosomal changes (protuberances,absence of condensation and chromosomal bridges) are principally given by I.P.C. I.P.C. and C.I.P.C. lead to the disappearance of the endoplasmic reticulum. These effects are correlated with the action of the two pesticides on DNA and protein synthesis.