[Changes of reactivity of rabbit lymphocyte xenoantigens following hormone treatment (author's transl)]

The experiments were performed on 8 rabbits which had been applied Hydrocortisone, Agostilben, Agovirin or Neolutin and which were followed for changes of reactivity of lymphocyte xenoantigens using human cytotoxic polyspecific sera. During hormone administration lymphocyte polyreactivity appeared. With hormone application stopped (day 10 and 24) polyreactivity became lost and substantial weakening or total loss of cytotoxic reactivity appeared in rabbits which had been applied Hydrocortisone or Agostilben. On day 38 polyreactivity of lymphocyte again appeared. The mechanisms of the origin of xenoantigenic modifications in rabbits are discussed. The results confirm the theory of the author about the modificating effect of hormones on lymphocyte antigens.