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Human alloimmune sera against T cell subsets. Detection and influence on pokeweed mitogen-stimulated Ig production in
Sera from multiparous women contain antibodies against T cell subsets. Population and family studies of four anti-T cell-subset antibodies are given. Two of these reacted with part of the suppressor T cell fraction (T gamma) and two with part of the helper T cell fraction (T mu) cells. By mixing T gamma- and mu-enriched cell suspensions in different concentrations, preliminary evidence was obtained that the anti-T cell-subset sera recognized T cells that had different functions in pokeweed mitogen-stimulated cytoplasmic immunoglobulin synthesis.
Sera from multiparous women contain antibodies against T cell subsets. Population and family studies of four anti-T cell-subset antibodies are given. Two of these reacted with part of the suppressor T cell fraction (T gamma) and two with part of the helper T cell fraction (T mu) cells. By mixing T gamma- and mu-enriched cell suspensions in different concentrations, preliminary evidence was obtained that the anti-T cell-subset sera recognized T cells that had different functions in pokeweed mitogen-stimulated cytoplasmic immunoglobulin synthesis.