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Related Experiment Videos

Immunoprotein deposition in the cornea.

K H Miller, W R Green, W J Stark

    Ophthalmology
    |September 1, 1980
    PubMed
    Summary

    Rheumatoid arthritis patients can develop immune-complex corneal deposits. Autopsy revealed immunoglobulin deposits in the eyes, linked to an unsuspected lymphoproliferative disorder.

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    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Immunology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • RA is associated with systemic immune-complex deposition.
    • Ocular manifestations of RA are common but corneal deposits are rare.

    Observation:

    • A 63-year-old woman with RA presented with bilateral corneal deposits.
    • Deposits were observed at all corneal levels, appearing as fine crystals and dense patches.
    • Autopsy revealed an unsuspected lymphoproliferative disorder and immune-complex disease.

    Findings:

    • Histopathology showed eosinophilic, PAS-positive, noncollagenous deposits in the cornea, ciliary processes, pars plana, and choroid.
    • Stains for gold, amyloid, and acid mucopolysaccharides were negative.
    • Immunoperoxidase stains confirmed deposits composed of IgG, IgA, kappa, and lambda light chains, consistent with immune complexes.
    • Electron microscopy identified needle-like extracellular particles presumed to be immunoglobulins.

    Implications:

    • This case highlights a rare ocular manifestation of immune-complex disease in RA.
    • Corneal deposits may be associated with underlying lymphoproliferative disorders.
    • Understanding these deposits aids in diagnosing and managing complex RA-related ocular complications.

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