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Related Experiment Videos

Plasma C19-delta 5-steroid levels during normal human pregnancy.

C E Bird, S J Cook, D E Dressel

    Clinical Biochemistry
    |June 1, 1980
    PubMed
    Summary

    During pregnancy, dehydroepiandrosterone sulfate and dehydroepiandrosterone levels decline. However, delta 5-androstenediol levels remained stable, with increased binding to plasma proteins observed in women.

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    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Steroid Biochemistry

    Background:

    • Dehydroepiandrosterone sulfate (DHEA-S) and dehydroepiandrosterone (DHEA) are key androgens.
    • Pregnancy involves significant hormonal shifts affecting steroid metabolism.
    • Understanding maternal steroid profiles is crucial for monitoring pregnancy health.

    Purpose of the Study:

    • To investigate the dynamic changes in specific androgen levels during pregnancy.
    • To analyze the behavior of delta 5-androstenediol and its protein binding throughout gestation.

    Main Methods:

    • Serial blood sampling from pregnant women.
    • Quantification of plasma dehydroepiandrosterone sulfate, dehydroepiandrosterone, and delta 5-androstenediol.
    • Assessment of delta 5-androstenediol binding to plasma proteins.

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    Main Results:

    • Plasma concentrations of dehydroepiandrosterone sulfate and dehydroepiandrosterone showed a decreasing trend.
    • Plasma levels of delta 5-androstenediol remained relatively constant during pregnancy.
    • An increase in the binding of delta 5-androstenediol to plasma proteins was observed.

    Conclusions:

    • Pregnancy is associated with a decline in DHEA and DHEA-S levels.
    • Delta 5-androstenediol exhibits distinct metabolic and binding characteristics compared to DHEA and DHEA-S during gestation.
    • Altered protein binding may influence the bioavailability of delta 5-androstenediol in pregnancy.