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Related Experiment Videos

Gonadal function in trisomy 21.

J Hasen, R M Boyar, L R Shapiro

    Hormone Research
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study found elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in individuals with trisomy 2, indicating impaired germinal and Leydig cell function. FSH measurement and testicular volume assessment are recommended for diagnosis.

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    Area of Science:

    • Endocrinology
    • Genetics
    • Reproductive Medicine

    Background:

    • Trisomy 2 is associated with hypogonadism.
    • Endocrine dysfunction in trisomy 2 requires further investigation.

    Purpose of the Study:

    • To evaluate the endocrinologic profile of patients with trisomy 2 and hypogonadism.
    • To determine the diagnostic approach for germinal cell function in this population.

    Main Methods:

    • Endocrinologic evaluation of 39 patients with trisomy 2.
    • Measurement of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and estradiol levels.
    • Assessment of testicular volume in males.

    Main Results:

    • Elevated FSH and LH levels were observed, suggesting impaired germinal and Leydig cell function.

    Related Experiment Videos

  • A negative correlation between testicular size and FSH levels was found.
  • Testosterone and estradiol levels were normal in males and females, respectively.

    • Conclusions:

    • Germinal and Leydig cell functions are affected in trisomy 2.
    • A simple diagnostic approach involves FSH measurement and testicular volume assessment in males.