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Related Experiment Videos

Plasmapheresis in multiple sclerosis: preliminary findings.

P C Dau, J H Petajan, K P Johnson

    Neurology
    |October 1, 1980
    PubMed
    Summary
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    Plasmapheresis therapy, combined with other treatments, showed modest neurologic improvement in progressive multiple sclerosis patients. This suggests blood-borne factors may drive the disease and could be reversible.

    Area of Science:

    • Neurology
    • Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
    • The role of blood-borne factors in MS pathogenesis remains under investigation.

    Observation:

    • Seven of eight patients with progressive MS receiving long-term plasmapheresis, azathioprine, and pulsed prednisone showed mild neurologic improvement.
    • Cerebrospinal fluid IgG levels decreased in six of seven patients.
    • Three patients with severe MS exacerbations refractory to prednisone recovered substantially following plasmapheresis.

    Findings:

    • Plasmapheresis therapy may improve neurologic function and reduce IgG levels in MS patients.
    • Clinical improvement in some patients was correlated with enhanced somatosensory evoked potentials.
    • No changes were observed in auditory/visual evoked responses or serum demyelinating activity.

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    Implications:

    • Blood-borne factors, potentially autoantibodies, may contribute to MS pathogenesis.
    • MS lesions might be partially reversible with plasmapheresis.
    • Further controlled trials are necessary to validate these preliminary findings.