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Histamine H2 receptors and intrinsic factor secretion.
Scandinavian Journal of Gastroenterology
|January 1, 1980
Summary
Cimetidine reduced intrinsic factor (IF) output but not concentration, suggesting different pathways for acid and IF secretion. Histamine H2 receptors are not essential for IF secretion.
Area of Science:
- Gastroenterology
- Physiology
- Pharmacology
Background:
- Intrinsic factor (IF) is crucial for vitamin B12 absorption.
- Parietal cells secrete both acid and IF.
- The role of histamine H2 receptors in IF secretion is not fully understood.
Purpose of the Study:
- To investigate the effect of cimetidine and impromidine on intrinsic factor secretion.
- To explore the intracellular pathways involved in parietal cell secretion.
- To determine the role of histamine H2 receptors in IF release.
Main Methods:
- Studied intrinsic factor secretion in healthy males.
- Utilized pentagastrin stimulation with and without cimetidine.
- Administered impromidine, a histamine H2 receptor agonist.
Main Results:
- Cimetidine reduced peak and total IF output, but IF concentration remained unchanged.
- A one-week administration of cimetidine did not affect the IF response.
- Impromidine elicited an IF secretory response similar to pentagastrin.
Conclusions:
- Histamine H2 receptors do not play an obligatory role in intrinsic factor secretion.
- Acid and IF secretion may involve distinct intracellular signaling pathways.
- Cimetidine likely does not alter intrinsic factor synthesis.