Related Experiment Videos
[Progressive occlusive disease of cerebral arteries associated with Down's syndrome. Report of a case]
Arquivos De Neuro-Psiquiatria
|June 1, 1980
Insights
This report details a 5-year-old with Down syndrome and Moyamoya disease, showing artery permeability. A potential microcirculatory disorder involving an unknown constrictive substance is suggested.
Area of Science:
- Neurology
- Genetics
- Pediatrics
Background:
- Down syndrome is a genetic disorder associated with various health complications.
- Moyamoya disease is a rare, progressive cerebrovascular disorder characterized by stenosis of the terminal portion of the internal carotid artery and the beginning of the middle and anterior cerebral arteries.
Observation:
- A 5-year-old child presented with the co-occurrence of Down syndrome and Moyamoya disease.
- Imaging revealed permeability of the internal carotid, medial, and anterior cerebral arteries.
Findings:
- The observed arterial alterations suggest a potential microcirculatory disorder.
- The bilateral and distributed nature of the lesions may be attributed to an unknown vasoactive substance with constrictive properties.
Implications:
- This case highlights a rare association between Down syndrome and Moyamoya disease in pediatric patients.
- Further research into the underlying mechanisms of this association could elucidate novel therapeutic targets for cerebrovascular disorders.
Abstract:
The case of a 5 years old child with association of "moyamoya" and Down syndrome with permeability of internal carotid, of medial and anterior cerebral arteries is reported. The authors postulate the possibility of a microcirculatory disorder in view of the distal lesion including the action of any unknown substance which constrictive action could explain the bilaterality and distribution of the alterations.