[Study of substances analagous to dimaprit affecting gastric secretion in vitro]

In the present paper the authors describe the effects of Dimaprit analogs on guinea pig gastric mucosa "in vitro". This preparation, widely described by Holton and Spencer, is useful for studying the actions of stimulants and inhibitors which act directly on the oxyntic cells. Such compounds are weakly active as stimulants of H2-receptors and studied as antagonists fail in inhibiting acid secretion evoked by Dimaprit, the most specific H2-receptors agonist. In particular, the compound marked Ros 5 clarifies that the isothiourea group of Dimaprit simulates the amidine system only chemically but not pharmacologically. The different mechanism of Dimaprit and Histamine on H2-receptors has been discussed.