[Mitotic activity of cervical cancer cells under different teleirradiation regimens]

Radiation pathomorphosis of cervical cancer stage I-II was estimated quantitatively in a comparative aspect under 4 different regimens of distance split-course irradiation, being the first step of an associated radiotherapy. Irradiation (using the Luch-1 machine) consisted of two two-week steps with an interval of 14-21 days. Tumor foci were given a total of 1800 rad during each step. An efficacy of radiation exposure in daily irradiation (180 radx5) was lowered as compared with an average fractionation (450 radx2). Fractionation of a daily dosage (225 radx2 with an interval of 5-6 hours and 150 radx3 with a 3 hour interval) was followed by less effect of radiation exposure, mostly manifest in triple fractionation of a daily dosage.