[Metabolic disorders in the myocardium in noncoronarogenic diseases]

Metabolic disorders develop in the myocardium in its noncoronarogenic diseases as a consequence of changes in the myocardiocyte electrolyte balance, disturbed energy potential of the muscle cell, changes in the properties of the myoplasm protein, and the direct damaging action on the cell organnelles. The authors studied the metabolic processes in the myocardium in myocardial dystrophy, myocarditis, and cardiomyopathy (55 cases). Subendomyocardial biopsy was conducted in 18 patients, post-mortem material was studied in 42 cases. Electron microscopy and histochemical studies were carried out. It was established that the morphological manifestations of metabolic disorders in the myocardium in its noncoronarogenic diseases are very diverse: these are disorders of oxidative processes and ATP synthesis, protein metabolism, glycogen metabolism, electrolyte balance, etc. A conclusion is drawn that it is necessary to record these changes in the treatment of noncoronarogenic myocardial diseases.