[Immunogenic properties of adenocarcinoma of mouse large intestine]

The immunogenecity of a transplantable carcinoma, which has spontaneously developed from embryonal colonic tissues, ectopically transplanted into adult syngeneic mice, was investigated. Three methods were employed to check the immunogenicity of the tumor: 1) transplantation and subsequent surgical removal of the tumor; 2) injection of irradiated tumor cells, the effect of immunization in both cases was detected by the decreased weight of tumors, repeatedly transplanted into the immunized animals; 3) mice were immunized according to the 2nd method, the effect of the immunization was defined by calculating the number of tumors, arisen in lungs of mice injected i. v. tumoral cells. The 3rd method was found to be mostly sensitive. Significant differences in the immunogenicity of different passages of carcinoma were noted. An antigenic similarity of adenocarcinoma concerned and colonic sarcoma developed under identical conditions was revealed.