Related Experiment Video
Updated: Aug 16, 2026

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins
Published on: August 31, 2017
Trisodium phosphonoformate inhibits woodchuck hepatitis virus associated DNA polymerase
Abstract:
Recently a new virus has been described which infects woodchucks, Marmota monax. This virus, named woodchuck hepatitis virus (WHV) is closely related to human hepatitis virus (HBV). The virions have the same principal antigenic system involving surface and core determinants and a serological relationship has been found. WHV has also a DNA polymerase associated with the core. It has previously been reported that trisodium phosphonoformate (PFA) but not phosphonoacetic acid (PAA) inhibits DNA polymerase associated with HBV. This investigation shows the same type of inhibition pattern by PFA and PAA on WHV DNA polymerase.
More Related Videos
Related Concept Videos
Restarting Stalled Replication Forks
Inhibitors of Bacterial DNA Synthesis
Inhibitors of Viral Protein Synthesis
Inhibitors Of Virion Release
Antiviral Nucleoside Inhibitors
Inhibitors of Virion Maturation and Assembly

