Experimental studies on the influence of the kallikrein-kinin system on glucose utilization

Our studies, together with the findings of other authors, indicate that kallikreins, via kinin release, play a role in glucose metabolism. It is most likely that the utilization of glucose is enhanced directly within the energy metabolizing cell itself but not indirectly by way of an insulin release in the pancreatic islets, since the in vitro studies on isolated islets of Langerhans did not reveal any effect of bradykinin on insulin secretion or insulin release. Further investigations are, however, necessary to clarify to what extent and in what way the kallikrein-kinin system is involved in causing the increased glucose utilization.