[Anti-inflammatory effect of aluminum or aurin tricarboxylic acid]

The anti-inflammatory effect of aurin tricarboxylic acid is studied in rats after parenteral injection of 20 and 50 mg/kg. Aurin tricarboxylic acid reduces: the carrageenan-induced oedemas in paws, the carragenan-induced pleural effusion, the carragen-induced granulation tissue growth and the Freund adjuvant-induced arthritis. As non steroïdal antiinflammatory drugs, the aurin tricarboxylic acid inhibits (ED50 = 0.34.10-2 M) the human erythrocyte delta aminolevulinic acid dehydratase, a zinc dependent enzyme. A possible interaction between zinc-enzymes and non steroïdal antiinflammatory compounds is suggested.