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Left ventricular function in chronic obstructive pulmonary disease.

C Gabinski

    Cor Et Vasa
    |January 1, 1980
    PubMed
    Summary
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    Left ventricular function in chronic obstructive lung disease patients was assessed. Right heart failure in cor pulmonale is not caused by left ventricular failure, despite altered left ventricular function.

    Area of Science:

    • Cardiology
    • Pulmonology
    • Physiology

    Background:

    • Chronic obstructive lung disease (COPD) can affect cardiac function.
    • Cor pulmonale, right heart failure due to lung disease, is common in COPD.
    • The impact of COPD and cor pulmonale on left ventricular (LV) function requires clarification.

    Purpose of the Study:

    • To investigate left ventricular (LV) function at rest and during post-extrasystolic potentiation (PESP) in patients with COPD.
    • To determine if right heart failure in cor pulmonale is secondary to LV dysfunction.

    Main Methods:

    • Studied 18 COPD patients, including 6 with cor pulmonale (Group B) and 12 without (Group A).
    • Assessed LV function using pressure and volume variations during rest and PESP.
    • Measured isovolumetric phase contractility indices and LV compliance.

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    Main Results:

    • LV function was similar between groups A and B.
    • LV was hypertrophied with altered pump function, but normal or increased kinetics.
    • Isovolumetric contractility indices were decreased but improved with PESP; LV compliance was altered due to hypertrophy and septal deviation.

    Conclusions:

    • Right heart failure in cor pulmonale is not secondary to left ventricular failure in COPD.
    • Impaired LV function in COPD is multifactorial, involving intrinsic factors (hypoxia, hypercapnia, hypertrophy) and extrinsic factors (RV hypertrophy, altered preload).
    • LV hypertrophy and interventricular septum deviation impact diastolic function.