Behavioral and EEG effects of synthetic enkephalin analogue (FK 33-824)

The behavioral and eeg changes induced by i.c.v. administration of FK 33-824, an active synthetic met-enkephalin analogue, were studied. The Monnier and Gangloff stereotaxic method was used in order to record cortical and deep structures. The effects of an opiate antagonist (naloxone) were examined. The aim of this research was to verify two hypotheses: whether or not there were any relationships between sedation state and eeg findings, and if any interactions could be detected between FK 33-824 and serotoninergic mechanisms.