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Related Experiment Videos

Enhanced thrombin and plasmin activity with exercise in man.

T M Hyers, B J Martin, D S Pratt

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |May 1, 1980
    PubMed
    Summary

    Exercise activates blood coagulation and fibrinolysis in vivo, indicated by increased thrombin and plasmin markers. Platelet activation, however, was not significantly affected by exercise intensity or type.

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    Area of Science:

    • Physiology
    • Hemostasis
    • Exercise Science

    Background:

    • Exercise is known to affect in vitro coagulation and fibrinolysis tests.
    • The in vivo relevance of these observed changes remains unclear.

    Purpose of the Study:

    • To investigate whether exercise-induced changes in coagulation and fibrinolysis observed in vitro reflect in vivo activity.
    • To measure markers of thrombin and plasmin action, and platelet release during exercise.

    Main Methods:

    • Measurements of plasma fibrinopeptide A (thrombin activity) and fibrin/fibrinogen-related D antigen (plasmin activity) during graded treadmill and cycle exercise.
    • Assessment of plasma-activated partial thromboplastin times and fibrin plate lysis areas.
    • Monitoring of platelet counts and plasma beta-thromboglobulin levels.

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    Main Results:

    • Plasma fibrinopeptide A levels increased 20-30 fold, and D antigen levels rose significantly with exercise intensity.
    • Activated partial thromboplastin times decreased as fibrinopeptide A increased, and fibrinolysis increased with rising D antigen.
    • Platelet counts and beta-thromboglobulin levels showed no significant changes during exercise.

    Conclusions:

    • Exercise activates the soluble coagulation and fibrinolytic systems in vivo.
    • Platelet activation does not appear to be significantly influenced by exercise.
    • The observed effects on thrombin and plasmin were independent of prior training but varied between treadmill and cycle exercise.