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[Prevalence of exfoliatin-producing strains in phage group II "Staphylococcus aureus" (author's transl)]
Abstract:
Prevalence of exfoliatin production has been investigated in 100 strains of Staphylococcus aureus, bacteriophage group II, by inoculation into newborn mice. Serotyping, detection of protein A and antibiotic susceptibility tests have also been performed. Thirty-one strains (31%) were toxin producers; they all produced a yellow pigment; there was no difference in phage attacks between toxinogenic and non-toxinogenic strains; but exfoliatin production was significantly associated to the presence of agglutinogens h2 and 263-2; rate of protein-A presence and of antibiotic susceptibility did not differ between the two groups of strains. In addition, toxin production has been investigated in 31 isolates from various skin lesions; 9 were found toxinogenic (8 amongst them had been cultivated from bullous lesions); most of them belonged to phage group II and possessed agglutinogens h2 and 263-2. So, in order to carry out the diagnosis of some bacterial skin infections, clinical symptoms, pathological and bacteriological data must be compared; the latter must include phage-typing, serotyping and exfoliatin detection.
Insights
Exfoliatin production in Staphylococcus aureus is linked to specific bacterial markers and skin lesions. Identifying these factors aids in diagnosing bacterial skin infections.
Area of Science:
- Microbiology
- Bacteriology
- Dermatology
Context:
- Staphylococcus aureus is a common pathogen.
- Exfoliatin is a key toxin produced by S. aureus.
- Understanding toxin production is crucial for diagnosing skin infections.
Purpose:
- To investigate the prevalence of exfoliatin production in Staphylococcus aureus.
- To identify associations between exfoliatin production and bacterial characteristics.
- To evaluate the utility of clinical and bacteriological data in diagnosing skin infections.
Summary:
- Exfoliatin production was observed in 31% of Staphylococcus aureus strains studied.
- Exfoliatin production was significantly associated with agglutinogens h2 and 263-2.
- Toxinogenic strains were frequently isolated from bullous skin lesions and belonged to phage group II.
Impact:
- This study highlights the importance of combining clinical, pathological, and bacteriological data for accurate diagnosis.
- Phage-typing, serotyping, and exfoliatin detection are valuable diagnostic tools for bacterial skin infections.
- Findings contribute to a better understanding of Staphylococcus aureus pathogenicity and diagnostic strategies.