[Effect of phosphonoacetic acid on experimental vaccinia infection]

The effect of phosphonoacetic acid (PAA) on reproduction of vaccinia virus in chick embryo fibroblast cultures and on the development of vaccinia virus infection in rabbits was studied. In vitro the preparation was tested as a solution, in vivo as a solution and ointment. In rabbits, the preparation was applied epicutaneously and inoculated subcutaneously and intravenously. All these routes were found to be effective. A single application conferred a much lower protective effect than daily administration for 4 days. Poly (I).poly (C) administered subcutaneously was found to be more effective than PAA. The latter in tissue culture exerted a marked inhibiting effect when used in a dose of 100 microgram/ml.