Comparison of gloxazone, an effective but toxic anaplasmacide, with imidocarb dihydrochloride

Eight calves and 15 steers were artificially infected with Anaplasma marginale. When parasitaemia reached 15 per cent, groups of animals were treated with either gloxazone (356C61), or imidocarb dihydrochloride or left untreated as controls. Both compounds were highly effective in the therapy of anaplasmosis. Toxicological studies showed that gloxazone was unacceptably toxic in lactating cattle and also caused nephrotoxicity in rats. Development work with gloxazone as an anaplasmacide has, therefore, been terminated but imidocarb is available.