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Related Experiment Videos

Clinical evaluation in acne.

S Lidén, K Göransson, L Odsell

    Acta Dermato-Venereologica. Supplementum
    |January 1, 1980
    PubMed
    Summary

    Oral zinc sulphate significantly improved acne vulgaris compared to placebo. This treatment was particularly effective for inflammatory acne, showing better results than for comedonal acne.

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    Area of Science:

    • Dermatology
    • Clinical Research Methodology

    Background:

    • Clinical evaluation of acne vulgaris treatments lacks standardized, sensitive methods.
    • Lesion counting is more reliable than patient opinion or photographic assessment for evaluating treatment efficacy.
    • Photographic assessment shows low correlation and reproducibility in acne studies.

    Purpose of the Study:

    • To compare the efficacy of oral zinc sulphate versus placebo in treating acne vulgaris.
    • To assess the sensitivity and reproducibility of different clinical evaluation methods for acne treatment.

    Main Methods:

    • A 6-week, double-blind, placebo-controlled study involving 54 patients.
    • Comparison of 0.6 g daily oral zinc sulphate against a placebo.
    • Clinical evaluation using lesion counts and a scoring system.

    Main Results:

    • Oral zinc sulphate treatment led to approximately a one-third improvement in acne.
    • Zinc sulphate showed a statistically significant improvement (p<0.05) compared to placebo.
    • Inflammatory acne (grades 2-3) responded better to zinc treatment than comedonal acne.

    Conclusions:

    • Oral zinc sulphate is an effective treatment for acne vulgaris, especially inflammatory types.
    • Lesion counting is a sensitive and reproducible method for evaluating acne treatment outcomes.

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