Preliminary model for streptozocin metabolism in mice

A mathematical model for streptozocin metabolism in mice is presented. By using the available bioassay and chemical assay data for a 300-mg/kg ip injection and the principles of physiologically based pharmacokinetics, a membrane-limited transport model with first-order kinetics was found to simulate the data adequately (average error of less than 20%). Furthermore, the first-order reaction constant derived in analyzing the bioassay data (0.009 min-1) was in close agreement with the half-life of streptozocin (1 hr) reported previously.