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Related Experiment Videos

[Muscle irritation study on cefoperazone (author's transl)].

S Nakamura, T Yoneda, A Takai

    The Japanese Journal of Antibiotics
    |October 1, 1980
    PubMed
    Summary

    Cefoperazone (CPZ) and similar cephalosporins cause moderate muscle injury in rabbits, comparable to acetic acid. Cephalothin (CET) induced more severe injury, though less than strong acetic acid.

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    Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the Gq/11 protein.

    British journal of pharmacology·2008

    Area of Science:

    • Pharmacology
    • Toxicology
    • Histopathology

    Context:

    • Antibiotic-induced muscular injury is a clinical concern.
    • Evaluating the myotoxicity of cephalosporins is crucial for safe administration.
    • Rabbit models are used to assess drug-induced tissue damage.

    Purpose:

    • To compare the muscular injury potential of cefoperazone (CPZ) with other cephalosporins (cefazolin, cephaloridine, cephalothin).
    • To assess the severity of muscular injury induced by these antibiotics in rabbits.
    • To evaluate the inflammatory response to these drugs in different age groups.

    Summary:

    • Cefoperazone (CPZ), cefazolin (CEZ), and cephaloridine (CER) caused similar degrees of muscular injury in rabbits, comparable to 0.75% acetic acid but more severe than saline.
    • Cephalothin (CET) induced more severe muscular injury than CPZ, CEZ, and CER, but less severe than 6% acetic acid.
    • The inflammatory reactions to these cephalosporins were similar in both adult and juvenile rabbits.

    Impact:

    • Provides comparative data on the myotoxicity of commonly used cephalosporins.
    • Informs clinical decisions regarding the selection and administration of cephalosporins to minimize muscle damage.
    • Highlights the differential myotoxic potential among cephalosporin antibiotics.

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