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Adherent suppressor cells in atopic disease.

I L Strannegård

    International Archives of Allergy and Applied Immunology
    |January 1, 1981
    PubMed
    Summary

    Adherent cells, likely monocytes/macrophages, show impaired function in some atopic children, impacting cell-mediated immunity. This suggests a potential role for these immune cells in the development of atopic disease.

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    Area of Science:

    • Immunology
    • Atopic Diseases
    • Cellular Immunology

    Background:

    • Atopic diseases involve complex immune dysregulation.
    • Adherent mononuclear cells, including monocytes/macrophages, play crucial roles in immune responses.
    • Previous studies have suggested but not definitively proven immune cell dysfunction in atopy.

    Purpose of the Study:

    • To investigate the function of adherent mononuclear cells in children with atopic conditions.
    • To evaluate two distinct suppressor cell systems for their ability to differentiate between atopic and non-atopic individuals.
    • To assess the role of adherent cells in modulating cellular responsiveness to mitogens.

    Main Methods:

    • Utilized two suppressor cell systems: an adherent cell suppressor system and a prostaglandin-related suppressor system.
    • Assessed suppressor cell activity in 54 atopic children and 23 controls.
    • Measured cellular responsiveness to phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) before and after partial removal of adherent cells.

    Main Results:

    • The adherent cell suppressor system identified disturbed function in 12/54 atopic children, indicated by negative suppressor tests, unlike controls.
    • No significant differences were found between atopic and non-atopic individuals using the prostaglandin-related suppressor system.
    • Partial removal of adherent cells increased PHA responsiveness but decreased PMA responsiveness.
    • The enhancing effect of adherent cells on mitogen responsiveness was significantly lower in atopic children compared to controls.

    Conclusions:

    • Results suggest a defective function of adherent cells, likely monocytes/macrophages, in a subset of atopic children.
    • This defect may be primary or secondary to other immune imbalances in atopy.
    • Impaired adherent cell function could have significant implications for cell-mediated immunity in atopic disease.

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