[Clinical experience with cefoperazone in the pediatric field (author's transl)]
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Cefoperazone (CPZ) effectively treated various bacterial infections in children. This antibiotic demonstrated significant clinical and bacteriological success with minimal side effects in pediatric patients.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology
- Bacteriology
Context:
- Acute bacterial infections in children pose significant health challenges.
- Intravenous administration of antibiotics is crucial for severe pediatric infections.
- Evaluating novel antibiotic efficacy in pediatric populations is essential.
Purpose:
- To assess the clinical and bacteriological effectiveness of Cefoperazone (CPZ) in treating acute bacterial infections in pediatric patients.
- To document the safety profile and side effects of Cefoperazone (CPZ) in children.
Summary:
- Cefoperazone (CPZ) was administered intravenously to 23 children with diverse acute bacterial infections, including pneumonia, urinary tract infections, septicemia, and meningitis.
- Clinical effectiveness was observed in 20 out of 23 cases, with bacteriological effectiveness in 14 out of 17 cases.
- Side effects were minimal, including transient diarrhea in one case and asymptomatic eosinophilia in two cases.
Impact:
- Cefoperazone (CPZ) is a valuable therapeutic option for managing a range of bacterial infections in pediatric patients.
- The study supports the use of Cefoperazone (CPZ) in pediatric infectious disease management.
- Findings contribute to evidence-based guidelines for antibiotic use in children.
Abstract:
Cefoperazone (CPZ) was given intravenously to 23 children with the following acute bacterial infections; 10 cases of pneumonia, 4 cases of urinary tract infection, 2 cases of purulent cervical lymphadenitis, 2 cases of pertussis pneumonia, 2 cases of septicemia, 1 case of osteomyelitis, 1 case of perforative peritonitis and 1 case of bacterial meningitis. Clinical effectiveness was obtained in 20 cases out of 23 cases and bacteriological effectiveness in 14 cases out of 17 cases. With CPZ, the following side effects developed; transient diarrhea in 1 case, asymptomatic eosinophilia in 2 cases. From the above clinical results, it is apparent that CPZ is a useful antibiotic for treating pediatric patients with various kinds of bacterial infections.