A proposed comprehensive pathophysiology of thrombotic thrombocytopenic purpura with implicit novel tests and therapies
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Updated: Aug 12, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Abstract:
The first detailed comprehensive hypothesis for the pathophysiology of TTP is proposed which accounts for all of the features of TTP at several levels of reference: clinical, physiologic, biochemical, hematologic, and tissue pathology. From the proposed pathophysiology, by deduction, a number of novel diagnostic tests and several rational, promising therapeutic modalities.
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