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Musculoskeletal syndromes associated with malignancy.
Seminars in Arthritis and Rheumatism
|February 1, 1981
Summary
Musculoskeletal syndromes can indicate underlying malignancies, prompting early cancer diagnosis and treatment. Some connective tissue diseases may increase cancer risk, potentially worsened by immunosuppressive drugs.
Area of Science:
- Rheumatology
- Oncology
- Pathogenesis
Background:
- Investigates the link between malignancies and musculoskeletal syndromes.
- Focuses on less common associations that mimic connective tissue diseases.
- Reviews common associations like hypertrophic osteoarthropathy and dermatomyositis elsewhere.
Observation:
- Discusses musculoskeletal syndromes that closely resemble primary connective tissue diseases.
- Highlights syndromes that can be presenting features of occult neoplasms.
- Notes that connective tissue syndromes may predispose individuals to malignancy.
Findings:
- Establishes a causal relationship between malignancies and musculoskeletal syndromes.
- Provides insights into the pathogenesis of primary connective tissue diseases.
- Suggests immunosuppressive therapy may enhance malignancy development in susceptible individuals.
Implications:
- Emphasizes the critical role of physician awareness of musculoskeletal symptoms for early cancer detection.
- Early diagnosis and treatment of malignancy improve patient outcomes.
- Understanding these associations aids in managing patients with both conditions.